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|
Outcome
|
D0
|
W8
|
p value
|
|---|
|
Vaginal mucosa thickness (N = 19)
|
|
Superficial
|
|
Median
|
28.41
|
26.36
|
p = 1
|
|
IQR
|
17.31; 38.78
|
21.5; 35.89
| |
|
Range
|
10.13; 116.88
|
10.6; 102.12
| |
|
Intermediate
| | | |
|
Median
|
114.4
|
112.5
|
p = 0.6507
|
|
IQR
|
85.58; 141.74
|
71.76; 162.12
| |
|
Range
|
40.6; 230.53
|
36.19; 237.26
| |
|
Basal
| | | |
|
Median
|
70.28
|
83.25
|
p = 0.8596
|
|
IQR
|
59.1; 103.79
|
63.78; 89.77
| |
|
Range
|
36.61; 128.23
|
36.69; 116.96
| |
|
Total
| | | |
|
Median
|
213.65
|
212.33
|
p = 0.5949
|
|
IQR
|
139.33; 300.76
|
175.09; 261.58
| |
|
Range
|
97.66; 439.7
|
86.65; 456.33
| |
|
Vaginal Flora (N = 11)
|
|
Nugent score
| | | |
|
Median
|
5
|
5
|
p = 0.5469
|
|
IQR
|
3; 7
|
3; 5
| |
|
Range
|
2; 8
|
1; 7
| |
|
Vaginal pH
| | | |
|
Vicinity of the injected area (N17)
| | | |
|
Median
|
6
|
5.5
|
p = 0.0574
|
|
IQR
|
5.5; 6.5
|
5; 6
| |
|
Range
|
5; 7.5
|
4.5; 7
| |
|
Lateral vaginal pouch (N = 19)
| | | |
|
Median
|
6
|
5.5
|
p = 0.0955
|
|
IQR
|
5.5; 7
|
4.5; 6.5
| |
|
Range
|
4; 7.5
|
4.5; 7.5
| |
|
Bachman VHI (N = 18)
|
|
VHI
| | | |
|
Median
|
12
|
21
|
p < 0.0001
|
|
IQR
|
10; 16
|
17; 22
| |
|
Range
|
5; 17
|
12; 25
| |
|
Procollagen I and III proteins mean fluorescence intensity/μm2 (N = 19)
|
|
Procollagen I mean fluorescence intensity/μm2
|
|
Median
|
47.87
|
61.91
|
p = 0.9843
|
|
IQR
|
35; 72.71
|
27.3; 82.78
| |
|
Range
|
16.06; 146.87
|
8.01; 145
| |
|
Procollagen III mean fluorescence intensity/μm2
|
|
Median
|
11.99
|
10.49
|
p = 0.7086
|
|
IQR
|
3.32; 27.36
|
4.6; 20.71
| |
|
Range
|
0.27; 72.27
|
0.7; 60.13
| |
|
COL1A1 and COL3A1 gene expression N = 19
|
|
COL1A1/GAPDH
|
|
Median
|
0.0035
|
0.0168
|
p = 0.0002
|
|
IQR
|
0.0014; 0.0053
|
0.0091; 0.0403
| |
|
Range
|
0.0006; 0.0151
|
0.0012; 0.1178
| |
|
COL3A1/GAPDH
|
|
Median
|
0.0003
|
0.0009
|
p = 0.0010
|
|
IQR
|
0.0002; 0.0005
|
0.0004; 0.0025
| |
|
Range
|
0.0001; 0.0012
|
0.0001; 0.0068
| |
|
Mitotic activity of the mucosa (Ki67) N = 19
|
|
Ki67 positive nucleus mean/mm2
|
|
Median
|
229.4
|
195.09
|
p = 0.8288
|
|
IQR
|
114.54; 426.16
|
76.76; 463.05
| |
|
Range
|
5.4; 695.26
|
0; 668.75
| |
